Can I cook this on HIGH instead of LOW?

Absolutely. If you’re short on time, set the slow cooker to HIGH for about 4-5 hours. The texture might be slightly different, but it’ll still be delicious and tender.

Do I need to add extra liquid to the slow cooker?

No need! The chuck roast and seasonings create plenty of savory juices as the beef cooks, resulting in a perfectly saucy pot roast.

Are the pepperoncini necessary?

They really finish the dish, giving it that subtle tang that makes Mississippi Pot Roast unique. If you’re sensitive to tart flavors, you can use fewer or leave them out, but most people find they mellow perfectly after hours of cooking.

What can I do with the leftovers?

Shredded Mississippi Pot Roast makes an amazing filling for tacos, sliders, stuffed baked potatoes, or even a creative pot pie—get creative!

Slow Cooker Mississippi Pot Roast Recipe

When comfort food meets ultimate ease, you get Slow Cooker Mississippi Pot Roast—a truly irresistible dinner that almost cooks itself! This dish delivers ultra-tender, flavor-packed beef with the tiniest effort, perfect for those jam-packed weeknights. The savory goodness of ranch and onion soup melds perfectly with buttery richness and a gentle zing from pepperoncini. If you’ve ever wished for a “set-it-and-forget-it” meal that feels special but is simple enough for a busy Tuesday, this is it.

Why You’ll Love This Recipe

Hands-Off and Hassle-Free: After a quick sear, your slow cooker does all the heavy lifting, giving you hours of hands-free cooking and a kitchen that smells like heaven by dinnertime.
Incredible Flavor: The combination of ranch dressing mix, onion soup mix, pepperoncini, and butter transforms a humble chuck roast into something magical—savory, tangy, and mouthwateringly rich.
Foolproof Results: As long as you stick the ingredients in the slow cooker and let them mingle, you’re guaranteed a juicy, shreddable dinner that feels like a treat.
Perfect for Crowds or Meal Prep: Whether you’re feeding hungry friends or planning ahead for lunches, this pot roast hits the mark on practicality and taste.

Ingredients You’ll Need

Chuck Roast: The star of the show. Chuck roast is perfect for slow cooking—its marbled texture ensures fork-tender, juicy results.
Vegetable Oil: Just a touch for searing, which adds deep flavor and helps lock in the juices.
Sea Salt & Ground Black Pepper: Basic seasonings that bring out the beef’s natural flavor before layering on other seasonings.
Ranch Dressing Mix: Brings a tangy, herbaceous note and subtle creaminess (don’t skip it!).
Onion Soup Mix: Adds a mellow, savory undertone—think umami in a packet.
Butter: The secret to extra richness and a silky sauce. Use real butter for best flavor.
Pepperoncini: These mild pickled peppers add a sleight zingy pop without overpowering, making the roast irresistible.

Note: You’ll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Variations

Want to put your own spin on this classic? Try one of these twists:

Spicy Version: Use hot pepperoncini or add a dash of red pepper flakes for some heat.
Low-Sodium: Opt for reduced-sodium soup and ranch mixes, and unsalted butter.
Different Cuts of Beef: Brisket or bottom round can stand in if chuck roast isn’t handy (just know the texture may vary slightly).
Make it Dairy-Free: Use a dairy-free butter substitute—flavors will still shine!
Extra Veggies: Throw chopped carrots or small baby potatoes around the roast for a one-pot meal.

How to Make Slow Cooker Mississippi Pot Roast

Step 1: Sear the Beef

Heat vegetable oil in a large skillet over high heat. Sear your chuck roast on all sides until deeply browned—this step amps up the flavor and ensures a beautiful crust.

Step 2: Layer the Seasonings

Transfer the seared roast into your slow cooker. Sprinkle with sea salt and black pepper, then layer the ranch dressing mix and onion soup mix evenly over the top.

Step 3: Add Butter and Pepperoncini

Place the stick of butter right on top of the roast. Add 6-8 pepperoncini around the meat. Don’t bother slicing—the whole peppers infuse just the right tang.

Step 4: Slow Cook

Cover and set to LOW. Let the slow cooker work its magic for 8 hours. No peeking—keeping the lid on locks in all the flavor and moisture.

Step 5: Shred and Serve

Once it’s fall-apart tender, shred the beef with two forks right in the slow cooker and mix it into all those luscious juices. Taste and adjust seasoning if needed.

Pro Tips for Making the Recipe

Brown for Flavor: Don’t skip searing. That deep brown crust makes a huge difference in taste.
Layer, Don’t Mix: Sprinkle seasonings and place butter on top—no stirring is needed.
Pepperoncini Power: Use the brine from the pepperoncini jar for an extra punch of tang.
Keep it Moist: Resist opening the lid while cooking—every time you do, precious steam escapes.
Shred in the Juices: Letting the beef soak up all the slow-cooked flavor makes it extra luscious.

How to Serve

Traditional: Pile the tender beef and its juices onto creamy mashed potatoes or fluffy white rice.
Sandwich Style: Load a soft toasted bun with pot roast, spoon on extra sauce, and top with more pepperoncini.
For a Lighter Meal: Serve over cauliflower mash, lavash wraps, or crisp salad greens.
Sides to Pair: Steamed green beans, roasted carrots, or a crisp slaw balance out the richness perfectly.

Add a sprinkle of fresh parsley if you’re feeling fancy!

Make Ahead and Storage

Storing Leftovers

Leftover pot roast is a lifesaver. Store in an airtight container, making sure to include plenty of the delicious juices, for up to 4 days in the fridge.

Freezing

Transfer cooled pot roast (with juices) to a freezer-safe container or bag. It keeps beautifully for up to 3 months. Thaw overnight in the refrigerator before reheating.

Reheating

Gently reheat in a covered saucepan over low heat, or use the microwave, adding a splash of broth or water if needed to loosen the sauce. The flavors deepen as it sits, so it might taste even richer the next day!

FAQs

Can I cook this on HIGH instead of LOW?

Absolutely. If you’re short on time, set the slow cooker to HIGH for about 4-5 hours. The texture might be slightly different, but it’ll still be delicious and tender.
Do I need to add extra liquid to the slow cooker?

No need! The chuck roast and seasonings create plenty of savory juices as the beef cooks, resulting in a perfectly saucy pot roast.
Are the pepperoncini necessary?

They really finish the dish, giving it that subtle tang that makes Mississippi Pot Roast unique. If you’re sensitive to tart flavors, you can use fewer or leave them out, but most people find they mellow perfectly after hours of cooking.
What can I do with the leftovers?

Shredded Mississippi Pot Roast makes an amazing filling for tacos, sliders, stuffed baked potatoes, or even a creative pot pie—get creative!

Final Thoughts

Few recipes offer so much payoff for so little effort as this Slow Cooker Mississippi Pot Roast. It’s deeply flavorful, wildly comforting, and could not be easier to pull off after a long day. Let the slow cooker do the heavy lifting while you look forward to a savory, tender, and unforgettable dinner. Give this recipe a try—you may just find yourself making it on repeat!